The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

@inproceedings{Paudyal2010TheNM,
  title={The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear},
  author={Anju Paudyal and Christine Damrau and Victoria L. Patterson and Alexander P. Ermakov and Caroline J Formstone and Zuzanna Lalanne and Sara Wells and Xiaowei Lu and Dominic P. Norris and Charlotte H Dean and Deborah J Henderson and Jennifer N. Murdoch},
  booktitle={BMC Developmental Biology},
  year={2010}
}
The planar cell polarity (PCP) signalling pathway is fundamental to a number of key developmental events, including initiation of neural tube closure. Disruption of the PCP pathway causes the severe neural tube defect of craniorachischisis, in which almost the entire brain and spinal cord fails to close. Identification of mouse mutants with craniorachischisis has proven a powerful way of identifying molecules that are components or regulators of the PCP pathway. In addition, identification of… CONTINUE READING
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