The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation.

@article{Sultan1990TheNI,
  title={The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation.},
  author={Ch Sultan and Monique Breton and G{\'e}rard Mauco and Pascal O Grondin and Monique Plantavid and Hugues Chap},
  journal={The Biochemical journal},
  year={1990},
  volume={269 3},
  pages={831-4}
}
Radioactive PtdIns(3)P was detected in human platelets incubated with [32P]Pi, but remained unaffected by thrombin treatment. In contrast, [32P]PtdIns(3,4)P2 was absent from resting platelets, but was produced by thrombin-activated platelets in a dose- and time-dependent manner. [32P]PtdInsP3 was never found under these conditions. These changes are similar to those elicited in other cells by platelet-derived growth factor or the oncogene product pp60c-src. 

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