The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

@inproceedings{Bavagnoli2015TheNI,
  title={The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA},
  author={Laura Bavagnoli and Stefano Cucuzza and Giulia Campanini and Francesca Rovida and Stefania Paolucci and Fausto Baldanti and Giovanni Maga},
  booktitle={Nucleic acids research},
  year={2015}
}
The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal aminoacids (aa) identical to PA, but with a completely different C-ter domain of 61 aa, due to a ribosomal frameshifting. In addition, it has been shown that several IAV isolates encode for a naturally truncated PA-X variant, PAXΔC20, missing the… CONTINUE READING
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