The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity.

@article{Efanov2001TheNI,
  title={The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity.},
  author={Alexandre M Efanov and Sergei V. Zaitsev and H J Mest and Achim Raap and Ioulia B. Appelskog and Olof Flodmark Elna - Marie Larsson and Per Olof Berggren and Suad Efend{\'i}c},
  journal={Diabetes},
  year={2001},
  volume={50 4},
  pages={797-802}
}
The insulinotropic activity of the novel imidazoline compound BL11282 was investigated. Intravenous administration of BL11282 (0.3 mg x kg(-1) x min(-1)) to anesthetized rats did not change blood glucose and insulin levels under basal conditions, but produced a higher increase in blood insulin levels and a faster glucose removal from the blood after glucose infusion. Similarly, in isolated Wistar rat pancreatic islets, 0.1-100 micromol/l BL11282 potently stimulated glucose-induced insulin… CONTINUE READING

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