The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.

@article{Miyake2008TheNH,
  title={The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.},
  author={Kotaro Miyake and M. Shimada and M. Nishioka and Koji Sugimoto and Erdenebulgan Batmunkh and Y. Uto and H. Nagasawa and H. Hori},
  journal={Cancer letters},
  year={2008},
  volume={272 2},
  pages={
          325-35
        }
}
Tumor hypoxia has been considered to be a potential therapeutic target, because hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. In the present study, we investigated the antitumor effect of hypoxic cell radiosensitizer, TX-1877 in inhibiting angiogenesis and liver metastasis on pancreatic cancer xenograft model. The antitumor effects of TX-1877 were tested against various human tumor cell lines using cell proliferation assay. Nude mice bearing s.c… Expand
Targeting hypoxic tumor microenvironment in pancreatic cancer
Hypoxic tumors and their effect on immune cells and cancer therapy.
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