The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers

  title={The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers},
  author={Qiao-yi Liang and J. Ding and R. Xu and Z. Xu and S. Zheng},
  journal={International Journal of Cancer},
The psiTPTE22 gene has been designated as a TPTE pseudogene. Our study found that the 5′ part of psiTPTE22 has no sequence similarity to TPTE and contains a 3.8‐kb human endogenous retrovirus (HERV) element. Because of the HERV element, the 5′ part of psiTPTE22 (psiTPTE22‐HERV) expresses independently as a gene. Comparison between the DNA sequences of humans and chimps indicated that psiTPTE22‐HERV is human specific. We identified 3 alternatively spliced transcript variants from psiTPTE22‐HERV… Expand
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