The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers

@article{Liang2010TheNH,
  title={The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers},
  author={Qiao-yi Liang and Jia-yi Ding and Rongzhen Xu and Ze-feng Xu and Shu Zheng},
  journal={International Journal of Cancer},
  year={2010},
  volume={127}
}
The psiTPTE22 gene has been designated as a TPTE pseudogene. Our study found that the 5′ part of psiTPTE22 has no sequence similarity to TPTE and contains a 3.8‐kb human endogenous retrovirus (HERV) element. Because of the HERV element, the 5′ part of psiTPTE22 (psiTPTE22‐HERV) expresses independently as a gene. Comparison between the DNA sequences of humans and chimps indicated that psiTPTE22‐HERV is human specific. We identified 3 alternatively spliced transcript variants from psiTPTE22‐HERV… 
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23 Citations

Expressional activation and functional roles of human endogenous retroviruses in cancers
TLDR
The current knowledge on the mechanisms of the expressional activation and functional roles of HERVs, with a focus on the H family HERV (HERV‐H), in carcinogenesis is summarized.
New insight into transcription of human endogenous retroviral elements.
LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM
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Predictions based on the ENSG00000203739/ENSG00000271646-miR-637-CYBRD1 and TPTEP1-MiR-196a-5p-RUFY2 regulation axes indicated that the two proteins may act as an oncogene and tumor suppressor, respectively, in the development of GBM.
Do the Human Endogenous Retroviruses Play a Role in Colon Cancer
TLDR
The state of the art for colon cancer with respect to the HERVs is reviewed to be considered as an open area of investigation, potentially leading to future innovative diagnostic and therapeutic approaches.
Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
TLDR
A tumor suppressing role of TPTEP1 in HCC progression is suggested and a novel understanding of T PTEP1 during the chemotherapy for HCC is provided.
ISR8/IRF1-AS1 Is Relevant for IFNα and NF-κB Responses
TLDR
Interestingly, disruption of ISR8 locus with CRISPR-Cas9 genome editing results in cells that fail to induce several key ISGs and pro-inflammatory cytokines after a trigger with IFNα or overexpression of IRF1 or the NF-κB subunit RELA, suggesting that the ISR 8 locus may play a relevant role in IFN α and NF-β pathways.
lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells
TLDR
It was validated that TPTEP1 sponged miR-328-5p to upregulate Src kinase signaling inhibitor 1 (SRCIN1) in NSCLC cells and indicated to inactivate the Src and STAT3 pathways in NS CLC cells.
Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer
TLDR
It is found that frameshift mutations of MLL3 in both CRC cells and primary tumor that were more common in cases with microsatellite instability are more common than usual.
Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response
TLDR
The transgenic expression of CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor, changes the mouse reservoir of hematopoietic stem cells in bone marrow and amplifies the mouse inflammatory response in a model of human systemic inflammatory response syndrome (SIRS).
Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
TLDR
Comparison of chromosome-wide DNA methylation patterns in normal and malignant prostate cells revealed significant methylation of gene-proximal and conserved intergenic sequences and can be easily extended for genome-wide methylation analysis in health and disease.
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