The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers
@article{Liang2010TheNH, title={The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers}, author={Qiao-yi Liang and J. Ding and R. Xu and Z. Xu and S. Zheng}, journal={International Journal of Cancer}, year={2010}, volume={127} }
The psiTPTE22 gene has been designated as a TPTE pseudogene. Our study found that the 5′ part of psiTPTE22 has no sequence similarity to TPTE and contains a 3.8‐kb human endogenous retrovirus (HERV) element. Because of the HERV element, the 5′ part of psiTPTE22 (psiTPTE22‐HERV) expresses independently as a gene. Comparison between the DNA sequences of humans and chimps indicated that psiTPTE22‐HERV is human specific. We identified 3 alternatively spliced transcript variants from psiTPTE22‐HERV… Expand
Topics from this paper
19 Citations
Expression Patterns of Non-Coding Spliced Transcripts from Human Endogenous Retrovirus HERV-H Elements in Colon Cancer
- Biology, Medicine
- PloS one
- 2012
- 35
- PDF
Expressional activation and functional roles of human endogenous retroviruses in cancers
- Biology, Medicine
- Reviews in medical virology
- 2019
- 17
New insight into transcription of human endogenous retroviral elements.
- Biology, Medicine
- New biotechnology
- 2013
- 14
LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM
- Biology, Medicine
- Frontiers in Oncology
- 2020
- 1
Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
- Biology, Medicine
- Journal of experimental & clinical cancer research : CR
- 2019
- 20
- Highly Influenced
lncRNA TPTEP1 competitively sponges miR-328-5p to inhibit the proliferation of non-small cell lung cancer cells
- Biology, Medicine
- Oncology reports
- 2020
- 7
- PDF
Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer
- Biology, Medicine
- PloS one
- 2011
- 63
- PDF
Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2019
- 10
- PDF
LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations
- Medicine, Biology
- Nucleic acids research
- 2018
- 43
- PDF
References
SHOWING 1-10 OF 38 REFERENCES
Identification of a novel human endogenous retrovirus and promoter activity of its 5' U3.
- Biology, Medicine
- Biochemical and biophysical research communications
- 2009
- 14
Sequence Variability, Gene Structure, and Expression of Full-Length Human Endogenous Retrovirus H
- Biology, Medicine
- Journal of Virology
- 2005
- 46
- PDF
Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3).
- Biology, Medicine
- Genomics
- 1999
- 113
An endogenous retroviral long terminal repeat is the dominant promoter for human β1,3-galactosyltransferase 5 in the colon
- Medicine, Biology
- Proceedings of the National Academy of Sciences of the United States of America
- 2003
- 116
- PDF
Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1996
- 193
- PDF
Differences in HERV-K LTR insertions in orthologous loci of humans and great apes.
- Biology, Medicine
- Gene
- 2000
- 70
- Highly Influential
The TPTE gene family: cellular expression, subcellular localization and alternative splicing.
- Biology, Medicine
- Gene
- 2003
- 80
High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection.
- Biology, Medicine
- Molecular biology and evolution
- 2005
- 115
- PDF