The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis.

@article{Tsutsumi1993TheNC,
  title={The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis.},
  author={Kazuhiko Tsutsumi and Yasuhide Inoue and Akiko Shima and Katsunori Iwasaki and Mitsunobu Kawamura and Toshio Murase},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 1},
  pages={411-7}
}
We have discovered a novel compound, NO-1886, which possesses a powerful lipoprotein lipase (LPL) activity-increasing action. Administration of NO-1886 increased LPL activity in the postheparin plasma, adipose tissue, and myocardium of rats, and produced a reduction in plasma triglyceride levels with concomitant elevation of HDL cholesterol levels. Administration of NO-1886 increased LPL enzyme mass in postheparin plasma and mRNA activity in epididymal adipose tissue, and it was concluded that… CONTINUE READING
41 Citations
18 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Heteroge - neous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency

  • T. Murase, N. Yamada, N. Arakawa, F. Takaku
  • J . Clin . Invest .
  • 1991

High - density lipoprotein : the clinical implications of recent studies

  • K. Haapa 0. Elo, P. Heinsalmi 0. P. Heinonen, +4 authors V. Manninen
  • N . Engl . J . Med .
  • 1989

Similar Papers

Loading similar papers…