The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells

@inproceedings{Zabel2011TheNC,
  title={The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells},
  author={Brian A. Zabel and Susanna Lewēn and Robert D. Berahovich and Juan C. Jaen and Thomas J. Schall},
  booktitle={Molecular Cancer},
  year={2011}
}
Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands (CCL19, CCL21, CXCL12 and CXCL13) by endothelial cells inside the lymph nodes facilitates the trans-endothelial migration (TEM) of these cells through high endothelial venules into the lymph node parenchyma. It is known that CXCR7, a second CXCL12… CONTINUE READING