The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat.

@article{Nagy2015TheNC,
  title={The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat.},
  author={L{\'a}szl{\'o} Nagy and Andras Kovacs and Be{\'a}ta B{\'o}di and Enikő T. P{\'a}sztor and G{\'a}bor {\'A}. F{\"u}l{\"o}p and Attila Toth and I F {\'E}des and Zolt{\'a}n Papp},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 18},
  pages={
          4506-4518
        }
}
BACKGROUND AND PURPOSE Omecamtiv mecarbil (OM) is a novel cardiac myosin activator drug for inotropic support in systolic heart failure. Here we have assessed the concentration-dependent mechanical effects of OM in permeabilized cardiomyocyte-sized preparations and single skeletal muscle fibres of Wistar-Kyoto rats under isometric conditions. EXPERIMENTAL APPROACHES Ca2+ -dependent active force production (Factive ), its Ca2+ sensitivity (pCa50 ), the kinetic characteristics of Ca2… CONTINUE READING
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References

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Showing 1-10 of 49 references

Ca(2+) sensitising inotropes after cardiac surgery

JG Cleland, JR Teerlink, +3 authors CC Lang
Eur J Cardiothorac Surg • 2011
View 5 Excerpts
Highly Influenced

The effects of EMD 57033 on rigor tension in porcine skinned cardiac trabecula

S Palmer, S Di Bello, JW Herzig
Eur J Pharmacol • 1995
View 3 Excerpts
Highly Influenced

Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms.

Journal of applied physiology • 1993
View 3 Excerpts
Highly Influenced

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