The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.

@article{Mclaughlin2005TheNC,
  title={The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.},
  author={P J Mclaughlin and Cara M Brown and Keisha M Winston and Gian Thakur and Dai Lu and Alexandros Makriyannis and John D Salamone},
  journal={Behavioural pharmacology},
  year={2005},
  volume={16 5-6},
  pages={477-86}
}
Cannabinoid agonists have been shown to produce dose-related impairments in several measures of cognitive performance. However, it is unclear if low doses of cannabinoid CB1 agonists, or CB1 antagonists, can facilitate aspects of stimulus detection. The present study employed an operant procedure involving visual stimulus detection in rats. The task was found to be sensitive to the muscarinic acetylcholine antagonist scopolamine. The CB1 antagonist AM 251 did not affect stimulus detection… CONTINUE READING