The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury.

@article{Kupina2001TheNC,
  title={The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury.},
  author={Nancy C Kupina and Ravinder Nath and Eric Bernath and J. Inoue and Akira Mitsuyoshi and P. W. T. Yuen and Kevin K W Wang and Edward D. Hall},
  journal={Journal of neurotrauma},
  year={2001},
  volume={18 11},
  pages={1229-40}
}
A principal mechanism of calcium-mediated neuronal injury is the activation of neutral proteases known as calpains. Proteolytic substrates for calpain include receptor and cytoskeletal proteins, signal transduction enzymes and transcription factors. Recently, calpain inhibitors have been shown to provide benefit in rat models of focal head injury and focal cerebral ischemia. The present study sought to investigate, in experiment 1, the time course of calpain-mediated cytoskeletal injury in a… CONTINUE READING

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