The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells

@article{Garnier2013TheNA,
  title={The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells},
  author={Nicolas Garnier and Lucas A Petruccelli and Manuel Flores Molina and Maria Kourelis and S Kwan and Zuanel Diaz and Hyman M. Schipper and Akanksha Gupta and Sonia V del Rinc{\'o}n and Koren Kathleen Mann and Wilson H. Miller},
  journal={Leukemia},
  year={2013},
  volume={27},
  pages={2220-2228}
}
Darinaparsin (Dar) is a more potent cytotoxic arsenical than arsenic trioxide (ATO). We hypothesized that the increased cytotoxicity of Dar may be because of a decreased cytoprotective response. We observed that, unlike ATO, Dar does not induce heme oxygenase-1 (HO-1), even though it induces expression of other nuclear factor (erythroid-derived 2)-like 2 (NRF2)-dependent detoxifying enzymes to a greater extent than ATO, in both cancer cell lines and patient-derived leukemic cells. This… CONTINUE READING
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