The novel anxiolytic ELB139 displays selectivity to recombinant GABAA receptors different from diazepam

@article{Rabe2007TheNA,
  title={The novel anxiolytic ELB139 displays selectivity to recombinant GABAA receptors different from diazepam},
  author={H. Rabe and C. Kronbach and C. Rundfeldt and H. L{\"u}ddens},
  journal={Neuropharmacology},
  year={2007},
  volume={52},
  pages={796-801}
}
  • H. Rabe, C. Kronbach, +1 author H. Lüddens
  • Published 2007
  • Chemistry, Medicine
  • Neuropharmacology
  • A chemically heterogeneous group of compounds acts at the benzodiazepine (BZ) recognition site of the diverse gamma-aminobutyric acid type A (GABA(A)) receptor complexes which can assemble from more than 16 known subunits. Most 1,4-BZs like diazepam recognize all GABA(A)/BZ receptors containing the alpha1-3 or alpha5 together with any beta and the gamma2 subunit. Other compounds differentiate less, e.g. Ro15-4513, that additionally recognizes alpha4- and a6-containing receptors, or… CONTINUE READING

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