The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes.

@article{Noyer1995TheNA,
  title={The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes.},
  author={Maxime Bayon De Noyer and Michel Gillard and Alain C Matagne and Jean Pierre H{\'e}nichart and Ernst W{\"u}lfert},
  journal={European journal of pharmacology},
  year={1995},
  volume={286 2},
  pages={137-46}
}
Levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide, ucb L059) is a novel potential antiepileptic agent presently in clinical development with unknown mechanism of action. The finding that its anticonvulsant activity is highly stereoselective (Gower et al., 1992) led us to investigate the presence of specific binding sites for [3H]levetiracetam in rat central nervous system (CNS). Binding assays, performed on crude membranes, revealed the existence of a reversible, saturable and… CONTINUE READING

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