The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypothalamo-pituitary-adrenal axis.

@article{Delbende1991TheNA,
  title={The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypothalamo-pituitary-adrenal axis.},
  author={C. Delbende and V. Contesse and E. Moca{\"e}r and A. Kamoun and H. Vaudry},
  journal={European journal of pharmacology},
  year={1991},
  volume={202 3},
  pages={
          391-6
        }
}
The possible effect of tianeptine, a novel antidepressant agent, on the neuroendocrine response to stress was investigated in adult male rats. Tube restraint stress for 30 min induced a marked increase of plasma ACTH and corticosterone. A single i.p. injection of tianeptine (10 mg/kg), 120 min before stress caused a significant decrease of ACTH and corticosterone levels. In order to investigate the kinetics of the effect of tianeptine, the drug was injected at various times (from 15 min to 12 h… Expand
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