The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.

@article{Ghring1997TheNS,
  title={The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.},
  author={F G{\"o}hring and Brenda Schwab and Pierluigi Nicotera and Marcel Leist and Frank O Fackelmayer},
  journal={The EMBO journal},
  year={1997},
  volume={16 24},
  pages={7361-71}
}
The scaffold attachment factor A (SAF-A) is an abundant component of the nuclear scaffold and of chromatin, and also occurs in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. Evidence from previous experiments had suggested that SAF-A most likely has at least two different functions, being involved both in nuclear architecture and RNA metabolism. We now show that the protein has a novel scaffold-associated region (SAR)-specific bipartite DNA-binding domain which is independent from… CONTINUE READING
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