The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin.


A facile preparation of 2-aminomethyl-2-tricyclo[,7)]decaneacetic acid hydrochloride 5 (AdGABA) is described. The synthesis of AdGABA involves the hydrogenation of 2-cyano-2-tricyclo[,7)]decaneacetic acid 11, which was synthesized by two different synthetic routes. AdGABA was found to antagonize the pentylenetetrazole (PTZ) and… (More)


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