The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.

@article{Seo2004TheNE,
  title={The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.},
  author={Su Ryeon Seo and François Lallemand and Nathalie Ferrand and Marcia Pessah and S{\'e}bastien L'hoste and Jacques H. Camonis and Azeddine Atfi},
  journal={The EMBO journal},
  year={2004},
  volume={23 19},
  pages={3780-92}
}
Ubiquitin-dependent degradation plays an important role in the negative regulation of TGF-beta signaling. Here, we identify Tiul1 (for TGIF interacting ubiquitin ligase 1), a novel E3 ubiquitin ligase that inhibits TGF-beta signaling by targeting both the activated receptor and Smad2 for degradation. Tiul1 associates constitutively with Smad7 and induces degradation of the activated type I receptor without affecting the expression levels of Smad7. Tiul1 can also interact with Smad2 and the… CONTINUE READING

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