The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.

@article{Rosenquist2003TheND,
  title={The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.},
  author={Thomas A. Rosenquist and Elena I. Zaika and Andrea S. Fernandes and Dmitry O. Zharkov and Holly Miller and Arthur P. Grollman},
  journal={DNA repair},
  year={2003},
  volume={2 5},
  pages={581-91}
}
DNA damage mediated by reactive oxygen species generates miscoding and blocking lesions that may lead to mutations or cell death. Base excision repair (BER) constitutes a universal mechanism for removing oxidatively damaged bases and restoring the integrity of genomic DNA. In Escherichia coli, the DNA glycosylases Nei, Fpg, and Nth initiate BER of oxidative lesions; OGG1 and NTH1 proteins fulfill a similar function in mammalian cells. Three human genes, designated NEIL1, NEIL2 and NEIL3, encode… CONTINUE READING

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