The noradrenaline precursor l‐threo‐3,4‐dihydroxyphenylserine exhibits antinociceptive activity via central α‐adrenoceptors in the mouse

@article{Kawabata1994TheNP,
  title={The noradrenaline precursor l‐threo‐3,4‐dihydroxyphenylserine exhibits antinociceptive activity via central $\alpha$‐adrenoceptors in the mouse},
  author={A. Kawabata and K. Kasamatsu and N. Umeda and H. Takagi},
  journal={British Journal of Pharmacology},
  year={1994},
  volume={111}
}
1 Systemic (s.c. or p.o.) administration of l‐threo‐3,4‐dihydroxyphenylserine (droxidopa, l‐threo‐DOPS; l‐threo‐3,4‐dihydroxyphenylserine (droxidopa, l‐threo‐DOPS, l‐DOPS); noradrenaline precursor; antinociception; analgesia; α‐adrenoceptors; l‐aromatic amino acid decarboxylase 2 Antinociception elicited by l‐DOPS (400 mg kg−1, s.c.) was not affected by s.c. injection of benserazide, a peripherally preferential l‐aromatic amino acid decarboxylase inhibitor, but was suppressed by its… Expand
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It is indicated that L‐threo‐DOPS is gradually converted to NA by L‐aromatic amino acid decarboxylase in vivo and may be clinically useful as an oral pressor agent for the treatment of certain disorders related to hypotension. Expand
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TLDR
The results suggest that L-DOPS may act as an NE precursor in the brain and activate NE neurons by increasing the turnover rate of NE. Expand
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The results suggest that the L-threo-DOPS-induced increase in brain MHPG is not likely to originate in peripheral organs including the brain capillary, and that L-norepinephrine can be converted to NE by aromatic L-amino acid decarboxylase(AADC) in the brain parenchyma. Expand
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