The noradrenaline precursor l‐threo‐3,4‐dihydroxyphenylserine exhibits antinociceptive activity via central α‐adrenoceptors in the mouse

@article{Kawabata1994TheNP,
  title={The noradrenaline precursor l‐threo‐3,4‐dihydroxyphenylserine exhibits antinociceptive activity via central $\alpha$‐adrenoceptors in the mouse},
  author={A. Kawabata and K. Kasamatsu and N. Umeda and H. Takagi},
  journal={British Journal of Pharmacology},
  year={1994},
  volume={111}
}
1 Systemic (s.c. or p.o.) administration of l‐threo‐3,4‐dihydroxyphenylserine (droxidopa, l‐threo‐DOPS; l‐threo‐3,4‐dihydroxyphenylserine (droxidopa, l‐threo‐DOPS, l‐DOPS); noradrenaline precursor; antinociception; analgesia; α‐adrenoceptors; l‐aromatic amino acid decarboxylase 2 Antinociception elicited by l‐DOPS (400 mg kg−1, s.c.) was not affected by s.c. injection of benserazide, a peripherally preferential l‐aromatic amino acid decarboxylase inhibitor, but was suppressed by its… Expand
L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug.
Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems.
FR143166 attenuates spinal pain transmission through activation of the serotonergic system.
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