The nonsense-mediated decay RNA surveillance pathway.

  title={The nonsense-mediated decay RNA surveillance pathway.},
  author={Yao-Fu Chang and J. Saadi Imam and Miles F. Wilkinson},
  journal={Annual review of biochemistry},
Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination (nonsense) codons. If translated, these mRNAs can produce truncated proteins with dominant-negative or deleterious gain-of-function activities. In this review, we describe the molecular mechanism of NMD. We first cover conserved factors known to be involved in NMD in all eukaryotes. We then describe a unique protein complex that is deposited on mammalian mRNAs during… 

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

  • L. Maquat
  • Biology, Chemistry
    Nature Reviews Molecular Cell Biology
  • 2004
The acquisition and loss of mRNA-associated proteins accompanies the transition from the pioneer round to subsequent rounds of translation, and from translational competence to substrate for nonsense-mediated mRNA decay.