The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.

@article{Hennard2001TheN,
  title={The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.},
  author={Christophe Hennard and Judith Finneman and Constance M Harris and Thomas M Harris and Michael P Stone},
  journal={Biochemistry},
  year={2001},
  volume={40 33},
  pages={
          9780-91
        }
}
  • Christophe Hennard, Judith Finneman, +2 authors Michael P Stone
  • Published in Biochemistry 2001
  • Chemistry, Medicine
  • Conformations of (R)-beta-(N(6)-adenyl)styrene oxide and (S)-beta-(N(6)-adenyl)styrene oxide adducts at position X(6) in d(CGGACXAGAAG).d(CTTCTTGTCCG), incorporating codons 60, 61 (underlined), and 62 of the human N-ras protooncogene, were refined from (1)H NMR data. These were designated as the beta-R(61,2) and beta-S(61,2) adducts. A total of 533 distance restraints and 162 dihedral restraints were used for the molecular dynamics calculations of the beta-S(61,2) adduct, while 518 distances… CONTINUE READING

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