The nongenomic effects of progesterone in repressing iNOS activation through P38MAPK pathways in gonococci-infected polymorphonuclear leukocytes and the clinical significance

@article{Chen2010TheNE,
  title={The nongenomic effects of progesterone in repressing iNOS activation through P38MAPK pathways in gonococci-infected polymorphonuclear leukocytes and the clinical significance},
  author={Rongyi Chen and Y. Tu and Jia-Xi Lin and Wei-Bing She and J. Li and Z. Wu and Li Xu and Hongxiang Chen},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2010},
  volume={30},
  pages={119-125}
}
  • Rongyi Chen, Y. Tu, +5 authors Hongxiang Chen
  • Published 2010
  • Biology, Medicine
  • Journal of Huazhong University of Science and Technology [Medical Sciences]
SummaryProgesterone has nongenomic effects on inducible nitric oxide synthase (iNOS), which is mediated by mitogen activated protein kinase (MAPK) pathways. This effect is supposed to have some potential association with asymptomatic gonococcal infections in women by immunological depression. In this study, polymorphonuclear leukocytes (PMNs) challenged by gonococci were used to study the nongenomic effects of progesterone. The activation of iNOS was assessed by measuring [3H] L-arginine… Expand
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