The nonenzymatic hydrolysis of oligoribonucleotides. VII. Structural elements affecting hydrolysis.

@article{Bibillo2000TheNH,
  title={The nonenzymatic hydrolysis of oligoribonucleotides. VII. Structural elements affecting hydrolysis.},
  author={A Bibillo and Marek Figlerowicz and Krzysztof Ziomek and Ryszard Kierzek},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2000},
  volume={19 5-6},
  pages={977-94}
}
Several elements of oligoribonucleotide structure are important for efficient hydrolysis. We have found that the following factors influence oligoribonucleotide hydrolysis: (i) single-stranded structure of RNA flanking the scissile phosphodiester bond, (ii) the substituent on atom C-5 of the uridine adjacent to the cleaved internucleotide bond, (iii) the position of the scissile UA phosphodiester bond within a hairpin loop, (iv) the concentration of formamide, urea, ethanol and sodium chloride. 

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