The non-steroidal SEGRA , BAY 1155975 , in contrast to classical glucocorticoids , inhibits anti-CD 28-costimulated T cell activation

Abstract

Glucocorticoids (GCs) are the most effective therapeutic agents for the treatment of acute and chronic inflammatory diseases. Their use is often accompanied with numerous and sometimes irreversible side-effects. Therefore, new glucocorticoid receptor (GR) ligands with should have potent anti-inflammatory efficacy but a reduced side-effect profile have been… (More)

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