The non-steroidal SEGRA , BAY 1155975 , in contrast to classical glucocorticoids , inhibits anti-CD 28-costimulated T cell activation


Glucocorticoids (GCs) are the most effective therapeutic agents for the treatment of acute and chronic inflammatory diseases. Their use is often accompanied with numerous and sometimes irreversible side-effects. Therefore, new glucocorticoid receptor (GR) ligands with should have potent anti-inflammatory efficacy but a reduced side-effect profile have been… (More)

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