The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia.

@article{Fan2015TheNG,
  title={The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia.},
  author={Hui Fan and Nian Gong and Tengfei Li and Ai-niu Ma and Xiao-yan Wu and Ming-Wei Wang and Yong-xiang Wang},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 1},
  pages={
          64-79
        }
}
BACKGROUND AND PURPOSE Two peptide agonists of the glucagon-like peptide-1 (GLP-1) receptor, exenatide and GLP-1 itself, exert anti-hypersensitive effects in neuropathic, cancer and diabetic pain. In this study, we have assessed the anti-allodynic and anti-hyperalgesic effects of the non-peptide agonist WB4-24 in inflammatory nociception and the possible involvement of microglial β-endorphin and pro-inflammatory cytokines. EXPERIMENTAL APPROACH We used rat models of inflammatory nociception… CONTINUE READING

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