The non-neuronal cholinergic system in health and disease.

  title={The non-neuronal cholinergic system in health and disease.},
  author={Janet Beckmann and Katrin Susanne Lips},
  volume={92 5-6},
Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing enzymes, transporters, receptors and degrading enzymes is termed the non-neuronal cholinergic system (NNCS). There is increasing evidence that the NNCS is dysregulated in various diseases and can have an influence on their pathology. However, for many organ systems not much is known about the expression and function of… CONTINUE READING