The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

@article{Gill1998TheNH,
  title={The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.},
  author={J. Gill and N. James and R. Roberts and C. Dive},
  journal={Carcinogenesis},
  year={1998},
  volume={19 2},
  pages={
          299-304
        }
}
The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both in vivo and in vitro. Here, we extend these observations by demonstrating the ability of nafenopin to suppress apoptosis induced by other major candidates for the signalling of… Expand
Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver.
  • S. Xiao, S. Anderson, +4 authors J. Corton
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2006
Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress
Cytokines in non-genotoxic hepatocarcinogenesis.
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