The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells.

@article{Chien2007TheNE,
  title={The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells.},
  author={Eileen Jea Chien and Ching-Fong Liao and Ching-Pang Chang and H J Pu and Li-ming Lu and Mei-Chi Shie and Dennis J-Y Hsieh and M Hsu},
  journal={Journal of cellular physiology},
  year={2007},
  volume={211 2},
  pages={544-50}
}
Progesterone is an endogenous immunomodulator and can suppress T-cell activation during pregnancy. We have previously shown that the non-genomic effects of progesterone, especially acidification, are exerted via plasma membrane sites and suppress cellular genomic responses to mitogens. This study aimed to show that acidification is due to a non-genomic inhibition of Na(+)/H(+)-exchange 1 (NHE1) by progesterone and correlate this with immunosuppressive phytohemagglutinin (PHA)-induced T-cell… CONTINUE READING

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