The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

@inproceedings{CasteloBranco2013TheNS,
  title={The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells},
  author={Gonçalo Castelo-Branco and Paulo P. Amaral and P{\"a}r G. Engstr{\"o}m and Samuel C. Robson and Sueli C. F. Marques and Paul Bertone and Tony Kouzarides},
  booktitle={Genome Biology},
  year={2013}
}
Pluripotency is characterized by a unique transcriptional state, in which lineage-specification genes are poised for transcription upon exposure to appropriate stimuli, via a bivalency mechanism involving the simultaneous presence of activating and repressive methylation marks at promoter-associated histones. Recent evidence suggests that other mechanisms, such as RNA polymerase II pausing, might be operational in this process, but their regulation remains poorly understood. Here we identify… CONTINUE READING
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