The non-cardiac systemic side-effects of antihistamines: ebastine.

@article{Roberts1999TheNS,
  title={The non-cardiac systemic side-effects of antihistamines: ebastine.},
  author={Derek J Roberts and Juan Domingo Gispert},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={1999},
  volume={29 Suppl 3},
  pages={151-5}
}
Ebastine and its active metabolite carebastine show potent antagonism of histamine H1-mediated phenomena in a wide variety of in vitro and in vivo non-clinical experimental models. By contrast, activity is not seen against histamine H2- or H3-mediated, nor acetylcholine- or serotonin-mediated phenomena, and both compounds are virtually without effect in models measuring pharmacological effects on the central nervous system (CNS). Explanation of these observations is found in their high… CONTINUE READING