The nociceptin/orphanin FQ (NOP) receptor antagonist J‐113397 enhances the effects of levodopa in the MPTP‐lesioned nonhuman primate model of Parkinson's disease

@article{Visanji2008TheNF,
  title={The nociceptin/orphanin FQ (NOP) receptor antagonist J‐113397 enhances the effects of levodopa in the MPTP‐lesioned nonhuman primate model of Parkinson's disease},
  author={Naomi P. Visanji and Rob M.A. de Bie and Tom H. Johnston and Andrew C McCreary and Jonathan M. Brotchie and Susan H. Fox},
  journal={Movement Disorders},
  year={2008},
  volume={23}
}
The anti‐parkinsonian and levodopa‐sparing potential of the nociceptin/orphanin FQ receptor (NOP) antagonist J‐113397 has been demonstrated in rodent models of Parkinson's disease. Here, we describe the levodopa‐sparing potential of J‐113397 in MPTP‐lesioned marmosets. Coadministration of J‐113397 (30 mg/kg) with a sub‐therapeutic dose of levodopa (12.5 mg/kg) produced an anti‐parkinsonian action equivalent to that of a therapeutic dose of levodopa. However, these effects were accompanied by an… 
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39 Citations

Nociceptin/Orphanin FQ Receptor Agonists Attenuate l-DOPA-Induced Dyskinesias

TLDR
N/OFQ receptor agonists may represent a novel strategy to counteract l-DOPA-induced dyskinesias and is possibly mediated by upregulated striatal N/OFq receptors opposing the D1 receptor-mediated overactivation of the striatonigral direct pathway.

Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK‐21273 in comparison with SB‐612111

TLDR
The acute and long‐term antiparkinsonian effects of the novel compound 2‐[3‐[4‐(2‐chloro‐6‐fluoro‐phenyl)‐piperidin‐1‐ylmethyl]‐2‐(morpholine‐4‐carbonyl)‐indol‐ 1‐yl]‐acetamide (NiK‐21273) in comparison with the potent and selective NOP receptor antagonist SB‐612111 is reported.

Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.

Managing Parkinson's disease: moving ON with NOP

TLDR
The opioid‐like neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP receptor) contribute to Parkinson's disease (PD) and motor complications associated with levodopa therapy and might represent a novel target in the therapy of PD.

Brain Interstitial Nociceptin/Orphanin FQ Levels are Elevated in Parkinson's Disease

  • M. MartiS. Sarubbo M. Morari
  • Biology, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 2010
TLDR
Data from this study provide the first clinical evidence linking N/OFQ to idiopathic Parkinson's disease in humans and strengthen the pathogenic role of N /OFQ in the modulation of parkinsonism across species and provide a rationale for developing N/ OFQ receptor antagonists as antiparkinsonian drugs.

Activation of Nociceptin/Orphanin FQ Peptide Receptors Disrupts Visual but Not Auditory Sensorimotor Gating in BALB/cByJ Mice: Comparison to Dopamine Receptor Agonists

TLDR
Results show that pharmacological stimulation of NOP or dopamine D2-like receptors is more potent in disrupting visual than acoustic PPI in mice, whereas D1-like receptor activation disrupts both, and suggest that dysfunction of N/OFQ transmission may be implicated in the pathogenesis of psychotic manifestations.

Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism

TLDR
It is demonstrated for the first time that N/OFQ is detrimental to the survival and growth of dopaminergic neurons and that its expression is altered in the midbrain of patients with Parkinson’s disease.

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

NOP Receptor Ligands and Parkinson's Disease.

TLDR
This chapter presents data showing that, in addition to motor symptoms, N/OFQ also plays a role in the parkinsonian neurodegeneration, and NOP receptor antagonists possess neuroprotective/neurorescue properties in in vitro and in vivo models of PD.

Nociceptinergic system as potential target in Parkinson's disease.

Nociceptinergic system has become an important target for drug development since the identification of the "orphan", opioid-like-1 receptor and the isolation of its endogenous agonist nociceptin.…

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