The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature.

  title={The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature.},
  author={Joanne L. Favaloro and Barbara K. Kemp-Harper},
  journal={Cardiovascular research},
  volume={73 3},
OBJECTIVE The nitroxyl anion (HNO) is the one-electron reduction product of NO(). This redox variant has been shown to be endogenously produced and to have effects that are pharmacologically distinct from NO(). This study investigates the vasodilator and chronotropic effects of HNO in the rat isolated coronary vasculature. METHODS Sprague-Dawley rat hearts were retrogradely perfused with Krebs' solution (8 ml/min) using the Langendorff technique. Perfusion pressure was raised using a… CONTINUE READING


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