The nitroxide stable radical tempo prevents metal-induced inhibition of CYP1A1 expression and induction.

@article{Faverney2000TheNS,
  title={The nitroxide stable radical tempo prevents metal-induced inhibition of CYP1A1 expression and induction.},
  author={Christine Risso-de Faverney and Marc Lafaurie and Jean Pierre Girard and Roger Rahmani},
  journal={Toxicology letters},
  year={2000},
  volume={111 3},
  pages={219-27}
}
Heavy metals are known to provoke oxidative stress in fish liver cells. Because H2O2, OH*- and intracellular superoxide are involved in this oxidation, we investigated the effect of nitroxide radical, 2,2,6,6-tetramethylpiperidinyl-N-oxyl (abbreviated as TEMPO), a cell-permeable agent possessing antioxidant properties, on CYP1A expression in trout (Oncorhynchus mykiss) hepatocytes. 3-methylcholanthrene (3-MC) induced the CYP1A-related EROD activity. This induction was inhibited by concomitant… CONTINUE READING