The nitrilase superfamily: classification, structure and function

  title={The nitrilase superfamily: classification, structure and function},
  author={Helen C Pace and Charles Brenner},
  journal={Genome Biology},
  pages={reviews0001.1 - reviews0001.9}
The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis and post-translational modification in plants, animals, fungi and certain prokaryotes. On the basis of sequence similarity and the presence of additional domains, the superfamily can be classified into 13 branches, nine of which have known or deduced specificity for specific nitrile- or amide-hydrolysis or amide-condensation reactions. Genetic and biochemical analysis of the family members and their… CONTINUE READING
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