The nitric oxide reductase of enterohaemorrhagic Escherichia coli plays an important role for the survival within macrophages.

@article{Shimizu2012TheNO,
  title={The nitric oxide reductase of enterohaemorrhagic Escherichia coli plays an important role for the survival within macrophages.},
  author={Takeshi Shimizu and Hiroyasu Tsutsuki and Akio Matsumoto and Haruaki Nakaya and M. T. Noda},
  journal={Molecular microbiology},
  year={2012},
  volume={85 3},
  pages={492-512}
}
In enterohaemorrhagic Escherichia coli (EHEC) O157, there are two types of anaerobic nitric oxide (NO) reductase genes, an intact gene (norV) and a 204 bp deletion gene (norVs). Epidemiological analysis has revealed that norV-type EHEC are more virulent than norVs-type EHEC. Thus, to reveal the role of NO reductase during EHEC infection, we constructed isogenic norV-type and norVs-type EHEC mutant strains. Under anaerobic conditions, the norV-type EHEC was protected from NO-mediated growth… CONTINUE READING
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