The nitric oxide hypothesis of aging

@article{McCann1998TheNO,
  title={The nitric oxide hypothesis of aging},
  author={S. McCann and J. Licinio and M. Wong and W. Yu and V. Rettorri},
  journal={Experimental Gerontology},
  year={1998},
  volume={33},
  pages={813-826}
}
Nitric oxide (NO), generated by endothelial (e) NO synthase (NOS) and neuronal (n) NOS, plays a ubiquitous role in the body in controlling the function of almost every, if not every, organ system. [...] Key Result Systemic injection of LPS causes induction of interleukin (IL)-1 beta mRNA followed by IL-beta synthesis that induces iNOS mRNA with a latency of two and four hours, respectively, in the anterior pituitary and pineal glands, meninges, and choroid plexus, regions outside the blood-brain barrier, and…Expand
Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease
Melatonin and nitric oxide
Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans
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