The nitric oxide donor LA-419 [S-(6-Nitro-oxi-hexahydro-furo[3,2-b]furan-3-1-il)thioacetate] prevents intestinal dysmotility, bacterial translocation, and inflammation in a rat model of enteritis.

@article{Porras2008TheNO,
  title={The nitric oxide donor LA-419 [S-(6-Nitro-oxi-hexahydro-furo[3,2-b]furan-3-1-il)thioacetate] prevents intestinal dysmotility, bacterial translocation, and inflammation in a rat model of enteritis.},
  author={M{\'o}nica Porras and Mar{\'i}a Teresa Mart{\'i}n and Evangelina Ter{\'a}n and M. Lourdes Mourelle and Patri Vergara},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 2},
  pages={740-8}
}
Indomethacin induces a chronic model of inflammatory bowel disease (IBD) characterized by spontaneous relapses of inflammation, bacterial translocation, and long-lasting motor disturbances derived from cyclical up-regulated inducible nitric-oxide synthase (iNOS) and sustained down-regulated neuronal NOS (nNOS). The aims of this study were to evaluate… CONTINUE READING