The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication.

@article{Murad1994TheNO,
  title={The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication.},
  author={Ferid Murad},
  journal={Recent progress in hormone research},
  year={1994},
  volume={49},
  pages={239-48}
}
  • Ferid Murad
  • Published 1994 in Recent progress in hormone research
From our work and that of others, it is now quite apparent that the NO-cGMP system can function as an intracellular or intercellular signal transduction system (Murad et al., 1988, 1990; Murad, 1989a,b; Ishii et al., 1989, 1991). If a specific cell possesses both NO synthase and an isoform of guanylyl cyclase that is activatable with NO, then cGMP levels in that cell can be regulated by agents that alter NO synthase activity and NO formation (Fig. 1). NO, or a complex of NO which is liberated… CONTINUE READING

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