The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.

Abstract

Oxidative stress and quasi-inflammatory processes recently have been recognized as contributing factors in the pathogenesis of Alzheimer's disease (AD). Reactive nitrating species have specifically been implicated in AD based on immunochemical and instrumental detection of nitrotyrosine in AD brain protein. The significance of lipid-phase nitration has not… (More)

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@article{Williamson2002TheNP, title={The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.}, author={Kelly S. Williamson and S Prasad Gabbita and Shenyun Mou and Melinda West and Quentin N. Pye and William R. Markesbery and Robert V. Cooney and Paula Grammas and Ulrich Reimann-Philipp and Robert A. Floyd and Kenneth L. Hensley}, journal={Nitric oxide : biology and chemistry}, year={2002}, volume={6 2}, pages={221-7} }