The nitration of tau protein in neurone-like PC12 cells.

  title={The nitration of tau protein in neurone-like PC12 cells.},
  author={Graziella Cappelletti and Gabriellla Tedeschi and Maria Grazia Maggioni and Armando Negri and Simona Nonnis and Rosalba Maci},
  journal={FEBS letters},
  volume={562 1-3},
Tyrosine nitration of proteins is emerging as a post-translational modification playing a role in physiological conditions. Looking for the molecular events triggered by nitric oxide in nerve growth factor-induced neuronal differentiation, we now find that nitration occurs on the microtubule-associated protein tau. In differentiated PC12 cells, we have identified as tau a nitrated protein that co-immunoprecipitates with alpha-tubulin and indicated that the modified protein is associated with… CONTINUE READING
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