The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

@article{Lundberg2008TheNO,
  title={The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics},
  author={J. Lundberg and E. Weitzberg and M. Gladwin},
  journal={Nature Reviews Drug Discovery},
  year={2008},
  volume={7},
  pages={156-167}
}
The inorganic anions nitrate (NO3−) and nitrite (NO2−) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism. However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical l-arginine–NO-synthase pathway, in particular in hypoxic states. This Review discusses the emerging important biological functions of the nitrate–nitrite–NO pathway, and highlights… Expand

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