The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy.

@article{Black2010TheNU,
  title={The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy.},
  author={J. E. Black and Daniel Pardi and Carl S Hornfeldt and Neil H. Inhaber},
  journal={Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine},
  year={2010},
  volume={6 6},
  pages={596-602}
}
OBJECTIVE To further explore the effects of sodium oxybate (SXB) administration on nocturnal sleep in narcolepsy patients during a double-blind, placebo-controlled, parallel group study conducted with 228 adult patients with narcolepsy/cataplexy in the United States, Canada, and Europe. METHOD Patients were withdrawn from antidepressants and sedative/hypnotics, and then randomized to receive 4.5, 6, or 9 g SXB or placebo nightly for 8 weeks. Patients receiving 6 and 9 g/night doses were… CONTINUE READING

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