The nicotinic modulation of [(3)H]D-aspartate outflow in primary cultures of rat neocortical neurons: effect of acute and long term nicotine treatment.

Abstract

The effect of nicotine 1 nM-10 microM on the efflux of [(3)H]D-aspartate was tested in primary cultures of rat cortical neurons kept at rest and subjected to electrical field stimulation. Two trains of pulses at 20 Hz for 20 s were applied at the 60th (St(1)) and 90th (St(2)) min of perfusion. The drug slightly and transiently increased the efflux of… (More)

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@article{Beani2000TheNM, title={The nicotinic modulation of [(3)H]D-aspartate outflow in primary cultures of rat neocortical neurons: effect of acute and long term nicotine treatment.}, author={Lorenzo Beani and Tiziana Antonelli and Maria Cristina Tomasini and Luca Marani and C. Bianchi}, journal={Neuropharmacology}, year={2000}, volume={39 13}, pages={2646-53} }