The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target.

@article{Offermanns2006TheNA,
  title={The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target.},
  author={Stefan Offermanns},
  journal={Trends in pharmacological sciences},
  year={2006},
  volume={27 7},
  pages={
          384-90
        }
}
Relatively high doses of nicotinic acid induce a profound change in the lipid and lipoprotein profile. In particular, the ability of nicotinic acid to decrease low-density lipoprotein cholesterol levels while increasing high-density lipoprotein cholesterol levels has led to its use as an antidyslipidemic drug. The mechanisms underlying the pharmacological effects of nicotinic acid have been unclear for decades. The recent discovery of a nicotinic acid receptor that is a G-protein-coupled… CONTINUE READING

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