The nicotine metabolite, cotinine, attenuates glutamate (NMDA) antagonist-related effects on the performance of the five choice serial reaction time task (5C-SRTT) in rats.

@article{Terry2012TheNM,
  title={The nicotine metabolite, cotinine, attenuates glutamate (NMDA) antagonist-related effects on the performance of the five choice serial reaction time task (5C-SRTT) in rats.},
  author={Alvin V. Terry and Jerry J. Buccafusco and Rosann F. Schade and Leah Vandenhuerk and Patrick Michael Callahan and Wayne D. Beck and Elizabeth Hutchings and James M. Chapman and Pei Li and Michael G Bartlett},
  journal={Biochemical pharmacology},
  year={2012},
  volume={83 7},
  pages={
          941-51
        }
}
Cotinine, the most predominant metabolite of nicotine in mammalian species, has a pharmacological half-life that greatly exceeds its precursor. However, until recently, relatively few studies had been conducted to systematically characterize the behavioral pharmacology of cotinine. Our previous work indicated that cotinine improves prepulse inhibition of the auditory startle response in rats in pharmacological impairment models and that it improves working memory in non-human primates. Here we… CONTINUE READING

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