The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release.

@article{Bordia2013TheND,
  title={The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release.},
  author={Tanuja Bordia and John McIntosh and Maryka Quik},
  journal={Journal of neurochemistry},
  year={2013},
  volume={125 2},
  pages={291-302}
}
l-dopa-induced dyskinesias (LIDs) are a side effect of Parkinson's disease therapy that is thought to arise, at least in part, because of excessive dopaminergic activity. Thus, drugs that regulate dopaminergic tone may provide an approach to manage LIDs. Our previous studies showed that nicotine treatment reduced LIDs in Parkinsonian animal models. This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function. Rats were unilaterally… CONTINUE READING
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