The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

  title={The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins},
  author={Cornelia R Bellamacina},
  journal={The FASEB Journal},
  pages={1257 - 1269}
  • C. Bellamacina
  • Published 1 September 1996
  • Biology, Chemistry
  • The FASEB Journal
Classical nicotinamide adenine dinucleotide (NAD+) binding proteins contain a βαβαβ unit. By comparing 14 such proteins, it is observed that an additional β strand associates with this unit to form the “core” topology, the minimum structure necessary to bind cofactor. Although the overall topologies of the cofactor binding domains of nicotinamide binding proteins vary, they all contain at least the core topology. The first 30‐35 amino acids of the core topology, called the “fingerprint” region… 

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