The niche for spermatogonial stem cells in the mammalian testis.

@article{Ogawa2005TheNF,
  title={The niche for spermatogonial stem cells in the mammalian testis.},
  author={Takehiko Ogawa and Masako Ohmura and Kazuyuki Ohbo},
  journal={International journal of hematology},
  year={2005},
  volume={82 5},
  pages={381-8}
}
The theory of the "stem cell niche" was originally proposed for the hematopoietic system, and the existence of the niche as an actual entity was proved in the Drosophila germ cell system. Historically, mammalian spermatogenesis has been studied extensively as a prime example of a stem cell system, and studies have established a stem-progenitor hierarchical order of spermatogonia. In the niche on the basal lamina of seminiferous tubules, spermatogonial stem cells (SSCs) are secluded from the… CONTINUE READING

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