The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.

  title={The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.},
  author={Byoung-Cheol Lee and Anant K. Menon and Alessio Accardi},
  journal={Biophysical journal},
  volume={111 9},
The TMEM16 family comprises Ca2+-activated Cl- channels and phospholipid scramblases. The crystal structure of a fungal homolog, nhTMEM16, revealed an important architectural feature of this protein family in the form of a bilayer-spanning hydrophilic groove that is directly exposed to the membrane. This groove likely provides a pathway for lipid translocation. As mutations that alter ion channel activity of the TMEM16 proteins localize around the groove, it was suggested that the ion and lipid… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 16 references

Identification of a lipid scrambling domain in ANO6/TMEM16F

  • K. Yu, J.M.Whitlock, H. C. Hartzell
  • Elife. 2015 Jun 9;4:e06901
  • 2015

TMEM16C facilitates Naþ-activated Kþ currents in rat sensory neurons and regulates pain

  • F. Huang, X. Wang, L. Y. Jan
  • 2013

Similar Papers

Loading similar papers…