The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.

@article{Lee2016TheNS,
  title={The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.},
  author={Byoung-Cheol Lee and Anant K. Menon and Alessio Accardi},
  journal={Biophysical journal},
  year={2016},
  volume={111 9},
  pages={
          1919-1924
        }
}
The TMEM16 family comprises Ca2+-activated Cl- channels and phospholipid scramblases. The crystal structure of a fungal homolog, nhTMEM16, revealed an important architectural feature of this protein family in the form of a bilayer-spanning hydrophilic groove that is directly exposed to the membrane. This groove likely provides a pathway for lipid translocation. As mutations that alter ion channel activity of the TMEM16 proteins localize around the groove, it was suggested that the ion and lipid… CONTINUE READING
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